MSH2-Pro™ Manufacturers Insert
Properties: The melanocyte-stimulating hormones (collectively referred to as MSH) are a class of polypeptide hormones that are produced by melanocyte cells, often in the intermediate lobe of the pituitary gland. During aging, MSH and its receptors decrease, thus causing some of the pale whiteness seen in many seniors, including those who are naturally dark-skinned.
MSH stimulates the production and release of melanin (melanogenesis) by melanocytes in skin and hair. Occasionally, MSH signals increased appetite (ghrelin) and sexual arousal.
An increase in MSH will cause skin darkening (hyperpigmentation) in humans. Melanocyte-stimulating hormones and estrogens increase naturally in humans during pregnancy, causing increased pigmentation. As a result of excess of the adrenocorticotropic hormone (ACTH), Cushing's syndrome may also result in hyperpigmentation, such as acanthosis nigricans in the axilla (darkening of the armpits). Most people with primary Addison's disease exhibit darkening of the skin, including areas not exposed to the sun; characteristic sites are skin creases, e.g. on the hands, nipples, and on the inside of the cheek (buccal mucosa) and gums. New scars become hyperpigmented, whereas older ones do not darken. This occurs because melanocyte-stimulating hormones (MSH) and adrenocorticotropic hormone (ACTH) share the same precursor molecule, pro-opiomelanocortin (POMC). Also, in some adrenal-deficient people lacking cortisol, ACTH becomes overactive and causes dotted pigmentation (freckling) of the skin.
Different levels of MSH are not the major cause of racial variation in skin color. However, in many red-headed people, fair-skinned people, and seniors who do not tan well, there are fewer hormone receptors, causing them to poorly respond to MSH in the blood. Thus, MSH2-Pro™ will not produce tanning in every person.
MSH2-Pro™ is a recombinant peptide product and contains the alpha isomer. Note: Technically the natural MSH is called an intermedin since it is produced in the intermediate lobe of the pituitary gland.
Directions: Apply one spray to one nostril only once daily (each spray is 10 IU). The maximum daily allowance for adults is 50 IU. The maximum dosage to be given at one time is 20 IU. Check blood pressure.
Caution: Although the hypertensive action of MSH is minimal when applied intra-nasally and in normal doses, it should be administered with caution if increased blood pressure is to be avoided. In cases of hypertension, advanced arteriosclerosis and epilepsy, this product should be administered with caution.
Contraindications: Coronary insufficiency; halothane or cyclopropane anesthetic.
Interactions: MSH is not known to be incompatible with any other medicine.
Side Effects: Side effects of a general nature are related to the nasal hypertensive activity described under ‘caution’. With normal doses, these are very mild or non-existent. Occasionally, it may produce rhinorrhea and nasal itchiness, headaches, conjunctivitis, sore throat, nausea, abdominal pain or the urgent need to defecate as a result of increased peristalsis.
Intoxication and its treatment: Symptoms of intoxication appear following the taking of very high doses, causing gastrointestinal upsets, intestinal hypermotility, increased blood pressure, collapse, stenocardiac disorders, cold sweats, pallor, problems in renal functioning, convulsions if there is already a predisposition, (for example, in the cases of epilepsy and ecampsia), and eventual uterine tetanization if taken during pregnancy. Treatment- Symptomatic therapy is only necessary in extreme cases: control of the circulatory system, or the hydrosaline metabolism and diuresis.
Presentation and use: 5 ml spray bottle. (1) Remove cap and squeeze 3 times before the first spray. (2) Introduce the spray bottle vertically into one nostril and squeeze once. The patient should then inhale gently. (3) Replace cap after use. Each spray delivers 10 IU; there is a total of 500 IU in a 5ml bottle.
Storage: The preparation may be kept at room temperature providing it is in a cool and dry place out of sunlight; it can also be kept in the cooler part of a fridge (i.e. the door). Once opened, use and throw away after one month.
Precautions: Keep this and all other medicines out of the reach of children. This product is not intended for use by pregnant or lactating women. This information does not replace your physician’s advice, always seek and follow your physician’s advice.
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